from www.AnimalExperiments.info :

Article explores the human predictivity of animal models

An article just published in Personalized Medicine has questioned contemporary reliance on animal models for investigating human diseases and responses to pharmaceuticals. The authors note that humans and animals are complex systems, in which small changes in initial conditions - including genetic makeup - can dramatically alter outcomes. One result is that animal models are often poorly predictive for humans. The article explores at length the relevant characteristics of complex systems, and genetic differences between and within species.

article: http://www.futuremedicine.com/doi/abs/10.2217/pme.11.89